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Multichain Immune Recognition Receptor Signaling: From Spatiotemporal Organization to Human Disease (Advances in Experimental Medicine and Biology)
| Штрих-код: | 9780387097886 (штрих-код верный) |
| Тип штрих-кода: | ISBN-13 |
| Страна: | Код для книг |
| Производитель: | (Не определено) |
| Торговая марка | (Не определено) |
| Категория: | Не определено |
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Описание:
Multichain Immune Recognition Receptors (MIRRs) represent a family of surface receptors expressed on different cells of the hematopoetic system and function to transduce signals leading to a variety of biologic responses. These receptors share common structural features, including extracellular ligand-binding domains and intracellular signaling domains carried on separate subunits. Another important feature linking members of the MIRR family is the presence of one or more copies of a cytoplasmic structural module termed the immunoreceptor tyrosine-based activation motif (ITAM). ITAMs consist of conserved sequences of amino acids that contain two appropriately spaced tyrosines (YxxL/Ix6–8YxxL/I; where x denotes non-conserved residues). Following receptor engagement, phosphorylation of ITAM tyrosine residues represents one of the earliest events in the signaling cascade. Although the MIRR-mediated ligand-recognition and the MIRR-triggered signaling cascades are believed to be among the...Тип обложки: Твердый переплет
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